MALT lymphoma-derived rheumatoid factors are nonpolyreactive high-affinity antibodies.
نویسندگان
چکیده
منابع مشابه
Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity
We analyzed the structure of antigen receptors of a comprehensive panel of mature B non-Hodgkin's lymphomas (B-NHLs) by comparing, at the amino acid level, their immunoglobulin (Ig)V(H)-CDR3s with CDR3 sequences present in GenBank. Follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas, and myelomas expressed a CDR3 repertoire comparable to that of normal B cells. Mantle cell...
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Gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) arises against a background of chronic inflammation caused by persistent Helicobacter pylori infection. The clinical and histopathologic features of the human tumor can be reproduced by Helicobacter infection of BALB/c mice. In this study, we have analyzed the antibody sequences and antigen specificity of a panel of murine and ...
متن کاملLYMPHOID NEOPLASIA Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins
Gastric B-cell lymphoma of mucosaassociated lymphoid tissue (MALT) arises against a background of chronic inflammation caused by persistent Helicobacter pylori infection. The clinical and histopathologic features of the human tumor can be reproduced by Helicobacter infection of BALB/c mice. In this study, we have analyzed the antibody sequences and antigen specificity of a panel of murine and h...
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OBJECTIVE B-cell expansion is a key feature of Sjögren's syndrome (SS). Accordingly, several studies have reported the benefits of B-cell depletion with anti-CD20 monoclonal antibody (Rituximab) in the treatment of glandular and extraglandular manifestations of SS. Patients with SS are at increased risk of lymphoma development. B-lymphocyte stimulator (BAFF) is an essential cytokine for the con...
متن کاملChronic hepatitis C virus and gastric MALT lymphoma.
Cases of lymphocytic monoclonal B-cell proliferation such as non-Hodgkin’s lymphomas have been reported in chronically hepatitis C virus (HCV)-infected patients. Lymphomas of the mucosa-associated lymphoid tissue (MALT) type are due to monoclonal proliferation of B cells showing characteristic histopathological features of MALT. Luppi et al1 recently reported an unexpectedly high prevalence of ...
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ورودعنوان ژورنال:
- Blood
دوره 116 10 شماره
صفحات -
تاریخ انتشار 2010